The major histocompatibility complex and multiple sclerosis: a smoking gun?
نویسندگان
چکیده
منابع مشابه
The major histocompatibility complex and multiple sclerosis: a smoking gun?
There are many theories on the aetiology of multiple sclerosis but most lack much in the way of direct experimental support. Despite overwhelming evidence that the pathogenesis involves an interplay between genetic and environmental effects, progress in identifying the relevant risk factors has been painfully slow and there is practically no understanding about how these might interact and resu...
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OBJECTIVE Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed. METHODS Using a c...
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Neurology 2012;79:1310–1311 Evidence of past infection with Epstein-Barr virus (EBV) and smoking are well-known risk factors for multiple sclerosis (MS). These 2 exposures together also are risk factors for several cancers, including nasopharyngeal carcinoma (NPC)1,2 and Hodgkin lymphoma (HL).3,4 For these diseases, EBV and smoking may be independent risk factors,1 associated with different his...
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OBJECTIVE To determine the relationship between highly-conserved extended-haplotypes (CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. BACKGROUND Among the ~200 MS-susceptibility regions, which are known from genome-wide analyses of single nucleotide polymorphisms (SNPs), the MHC accounts for roughly a third of the currently explained variance and the strongest MS-as...
متن کاملThe major histocompatibility complex.
The major histocompatibility complex on the sixth chromosome controls expression of a complex series of cell surface antigens which comprise the human leukocyte antigen (HLA) system. These markers, beyond their importance in human organ transplantation, have been demonstrated to occur with an increased prevalence in certain disease states. The group of conditions showing the closest association...
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ژورنال
عنوان ژورنال: Brain
سال: 2011
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awq384